Therapeutic Development in Cardiac Syndrome X: A Need to Target the Underlying Pathophysiology
نویسندگان
چکیده
منابع مشابه
Fragile X Syndrome: From Pathophysiology to New Therapeutic Perspectives
In the present chapter we will provide an overview of recent literature regarding new therapeutic perspectives in Fragile X syndrome (FXS), which are based on a rational approach well-grounded on a deeper understanding of the disease pathophysiology. FXS represents a paradigmatic example of how research can be translated into therapy targeting dysfunctional mechanisms rather than symptoms. Seve...
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Endothelial dysfunction which is manifested by the loss of nitric oxide bioavailability, is an increasingly recognized cause of cardiac syndrome X (CSX) and beta blockers are used for the treatment of this syndrome. Thus, the aim of this study was to investigate effects of metoprolol, as a beta blocker, on endothelial function in CSX patients. The study included 25 CSX patients (20 female/ 5 ma...
متن کاملMetoprolol improves endothelial function in patients with cardiac syndrome X
Endothelial dysfunction which is manifested by the loss of nitric oxide bioavailability, is an increasingly recognized cause of cardiac syndrome X (CSX) and beta blockers are used for the treatment of this syndrome. Thus, the aim of this study was to investigate effects of metoprolol, as a beta blocker, on endothelial function in CSX patients. The study included 25 CSX patients (20 female/ 5 ma...
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15 صفحه اولOpen-label treatment trial of lithium to target the underlying defect in fragile X syndrome.
OBJECTIVE In fragile X syndrome (FXS), it is hypothesized that absence of the fragile X mental retardation protein (FMRP) disrupts regulation of group 1 metabotropic glutamate receptor (mGluR and mGluR5)-dependent translation in dendrites. Lithium reduces mGluR-activated translation and reverses phenotypes in the dfxr mutant fly and fmr1 knockout mouse. This pilot add-on trial was conducted to ...
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ژورنال
عنوان ژورنال: Cardiovascular Therapeutics
سال: 2009
ISSN: 1755-5914,1755-5922
DOI: 10.1111/j.1755-5922.2008.00070.x